Most recent publications

*For the complete list go to https://www.ncbi.nlm.nih.gov/pubmed/?term=Cuello+AC

Differential effect of an evolving amyloid and tau pathology on brain phospholipids and bioactive lipid mediators in rat models of Alzheimer-like pathology.

Do Carmo S, Kautzmann MI, Bhattacharjee S, Jun B, Steinberg C, Emmerson JT, Malcolm JC, Bonomo Q, Bazan NG, Cuello AC.J Neuroinflammation. 2024 Jul 30;21(1):185. doi: 10.1186/s12974-024-03184-7.PMID: 39080670 Free PMC article.

Early oxidative stress and DNA damage in Aβ-burdened hippocampal neurons in an Alzheimer's-like transgenic rat model.

Foret MK, Orciani C, Welikovitch LA, Huang C, Cuello AC, Do Carmo S.Commun Biol. 2024 Jul 14;7(1):861. doi: 10.1038/s42003-024-06552-4.PMID: 39004677 Free PMC article.

Primacy of vision shapes behavioral strategies and neural substrates of spatial navigation in marmoset hippocampus.

Piza DB, Corrigan BW, Gulli RA, Do Carmo S, Cuello AC, Muller L, Martinez-Trujillo J.Nat Commun. 2024 May 14;15(1):4053. doi: 10.1038/s41467-024-48374-2.PMID: 38744848 Free PMC article.

Low TGF-β1 plasma levels are associated with cognitive decline in Down syndrome.

Grasso M, Fidilio A, L'Episcopo F, Recupero M, Barone C, Bacalini MG, Benatti C, Giambirtone MC, Caruso G, Greco D, Di Nuovo S, Romano C, Ferri R, Buono S, Cuello AC, Blom JMC, Tascedda F, Piazza PV, De La Torre R, Caraci F.Front Pharmacol. 2024 Mar 21;15:1379965. doi: 10.3389/fphar.2024.1379965. eCollection 2024.PMID: 38576478 Free PMC article.

The Effect of Fat Intake with Increased Omega-6-to-Omega-3 Polyunsaturated Fatty Acid Ratio in Animal Models of Early and Late Alzheimer's Disease-like Pathogenesis.

Galeano P, de Ceglia M, Mastrogiovanni M, Campanelli L, Medina-Vera D, Campolo N, Novack GV, Rosell-Valle C, Suárez J, Aicardo A, Campuzano K, Castaño EM, Do Carmo S, Cuello AC, Bartesaghi S, Radi R, Rodríguez de Fonseca F, Morelli L.Int J Mol Sci. 2023 Nov 30;24(23):17009. doi: 10.3390/ijms242317009.PMID: 38069333 Free PMC article.

Early treatment with an M1 and sigma-1 receptor agonist prevents cognitive decline in a transgenic rat model displaying Alzheimer-like amyloid pathology.

Orciani C, Do Carmo S, Foret MK, Hall H, Bonomo Q, Lavagna A, Huang C, Cuello AC.Neurobiol Aging. 2023 Dec;132:220-232. doi: 10.1016/j.neurobiolaging.2023.09.010. Epub 2023 Sep 26.PMID: 37864952

 Neuronal loss and inflammation preceding fibrillary tau pathology in a rat model with early human-like tauopathy.

Emmerson JT, Malcolm JC, Do Carmo S, Nguyen P, Breuillaud L, Martinez-Trujillo JC, Cuello AC.Neurobiol Dis. 2023 Oct 15;187:106317. doi: 10.1016/j.nbd.2023.106317. Epub 2023 Oct 5.PMID: 37802153 Free article.

Progressive human-like tauopathy with downstream neurodegeneration and neurovascular compromise in a transgenic rat model.

Emmerson JT, Do Carmo S, Liu Y, Shalhoub A, Liu A, Bonomo Q, Malcolm JC, Breuillaud L, Martinez-Trujillo JC, Cuello AC.Neurobiol Dis. 2023 Oct 15;187:106301. doi: 10.1016/j.nbd.2023.106301. Epub 2023 Sep 22.PMID: 37741743 Free article. No abstract available.

 Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome.

Rozalem Aranha M, Iulita MF, Montal V, Pegueroles J, Bejanin A, Vaqué-Alcázar L, Grothe MJ, Carmona-Iragui M, Videla L, Benejam B, Arranz J, Padilla C, Valldeneu S, Barroeta I, Altuna M, Fernández S, Ribas L, Valle-Tamayo N, Alcolea D, González-Ortiz S, Bargalló N, Zetterberg H, Blennow K, Blesa R, Wisniewski T, Busciglio J, Cuello AC, Lleó A, Fortea J.Alzheimers Dement. 2023 Nov;19(11):4817-4827. doi: 10.1002/alz.12999. Epub 2023

Nicotinamide as potential biomarker for Alzheimer's disease: A translational study based on metabolomics.

Dalmasso MC, Arán M, Galeano P, Perin S, Giavalisco P, Martino Adami PV, Novack GV, Castaño EM, Cuello AC, Scherer M, Maier W, Wagner M, Riedel-Heller S, Ramirez A, Morelli L.Front Mol Biosci. 2023 Jan 6;9:1067296. doi: 10.3389/fmolb.2022.1067296. eCollection 2022.PMID: 36685284 Free PMC article.

 Long-term nucleus basalis cholinergic depletion induces attentional deficits and impacts cortical neurons and BDNF levels without affecting the NGF synthesis.

Orciani C, Hall H, Pentz R, Foret MK, Do Carmo S, Cuello AC.J Neurochem. 2022 Oct;163(2):149-167. doi: 10.1111/jnc.15683. Epub 2022 Aug 26.PMID: 35921478 Free article.

[11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer's disease.

Pascoal TA, Chamoun M, Lax E, Wey HY, Shin M, Ng KP, Kang MS, Mathotaarachchi S, Benedet AL, Therriault J, Lussier FZ, Schroeder FA, DuBois JM, Hightower BG, Gilbert TM, Zürcher NR, Wang C, Hopewell R, Chakravarty M, Savard M, Thomas E, Mohaddes S, Farzin S, Salaciak A, Tullo S, Cuello AC, Soucy JP, Massarweh G, Hwang H, Kobayashi E, Hyman BT, Dickerson BC, Guiot MC, Szyf M, Gauthier S, Hooker JM, Rosa-Neto P.Nat Commun. 2022 Jul 19;13(1):4171. doi: 10.1038/s41467-022-30653-5.PMID: 35853847 Free PMC article.

Early loss of locus coeruleus innervation promotes cognitive and neuropathological changes before amyloid plaque deposition in a transgenic rat model of Alzheimer's disease.

Flores-Aguilar L, Hall H, Orciani C, Foret MK, Kovecses O, Ducatenzeiler A, Cuello AC.Neuropathol Appl Neurobiol. 2022 Oct;48(6):e12835. doi: 10.1111/nan.12835. Epub 2022 Jul 25.PMID: 35822518

mTORC2 mediates structural plasticity in distal nociceptive endings that contributes to pain hypersensitivity following inflammation.

Wong C, Barkai O, Wang F, Perez CT, Lev S, Cai W, Tansley S, Yousefpour N, Hooshmandi M, Lister KC, Latif M, Cuello AC, Prager-Khoutorsky M, Mogil JS, Séguéla P, De Koninck Y, Ribeiro-da-Silva A, Binshtok AM, Khoutorsky A.J Clin Invest. 2022 Aug 1;132(15):e152635. doi: 10.1172/JCI152635.PMID: 35579957 Free PMC article.

Reimagining cholinergic therapy for Alzheimer's disease.

Giacobini E, Cuello AC, Fisher A.Brain. 2022 Jul 29;145(7):2250-2275. doi: 10.1093/brain/awac096.PMID: 35289363 Review.

The Nerve Growth Factor Metabolic Pathway Dysregulation as Cause of Alzheimer's Cholinergic Atrophy.

Do Carmo S, Kannel B, Cuello AC.Cells. 2021 Dec 22;11(1):16. doi: 10.3390/cells11010016.PMID: 35011577 Free PMC article. Review.

Editorial: Tau Pathology in Neurological Disorders.

Do Carmo S, Spillantini MG, Cuello AC.Front Neurol. 2021 Sep 24;12:754669. doi: 10.3389/fneur.2021.754669. eCollection 2021.PMID: 34630315

Rita Levi-Montalcini, NGF Metabolism in Health and in the Alzheimer's Pathology.

Cuello AC.Adv Exp Med Biol. 2021;1331:119-144. doi: 10.1007/978-3-030-74046-7_9.PMID: 34453296

Nerve Growth Factor Compromise in Down Syndrome.

Do Carmo S, Kannel B, Cuello AC.Front Aging Neurosci. 2021 Aug 9;13:719507. doi: 10.3389/fnagi.2021.719507. eCollection 2021.PMID: 34434101

Preclinical in vivo longitudinal assessment of KG207-M as a disease-modifying Alzheimer's disease therapeutic.

Kang MS, Shin M, Ottoy J, Aliaga AA, Mathotaarachchi S, Quispialaya K, Pascoal TA, Collins DL, Chakravarty MM, Mathieu A, Sandelius Å, Blennow K, Zetterberg H, Massarweh G, Soucy JP, Cuello AC, Gauthier S, Waterston M, Yoganathan N, Lessard E, Haqqani A, Rennie K, Stanimirovic D, Chakravarthy B, Rosa-Neto P.J Cereb Blood Flow Metab. 2021 Aug 11:271678X211035625. doi: 10.1177/0271678X211035625. Online ahead of print.PMID: 34378436

Leslie Iversen, a friend of friends and an inspiring light in neuropharmacology.

Cuello AC.Proc Natl Acad Sci U S A. 2021 Aug 10;118(32):e2111813118. doi: 10.1073/pnas.2111813118.PMID: 34353919

Cognitive and brain cytokine profile of non-demented individuals with cerebral amyloid-beta deposition.

Flores-Aguilar L, Iulita MF, Orciani C, Tanna N, Yang J, Bennett DA, Cuello AC.J Neuroinflammation. 2021 Jul 4;18(1):147. doi: 10.1186/s12974-021-02169-0.PMID: 34218796

Liver X Receptor Activation with an Intranasal Polymer Therapeutic Prevents Cognitive Decline without Altering Lipid Levels.

Navas Guimaraes ME, Lopez-Blanco R, Correa J, Fernandez-Villamarin M, Bistué MB, Martino-Adami P, Morelli L, Kumar V, Wempe MF, Cuello AC, Fernandez-Megia E, Bruno MA.ACS Nano. 2021 Mar 23;15(3):4678-4687. doi: 10.1021/acsnano.0c09159. Epub 2021 Mar 5.PMID: 33666411

Hippocampal hyperactivity in a rat model of Alzheimer's disease.

Sosulina L, Mittag M, Geis HR, Hoffmann K, Klyubin I, Qi Y, Steffen J, Friedrichs D, Henneberg N, Fuhrmann F, Justus D, Keppler K, Cuello AC, Rowan MJ, Fuhrmann M, Remy S.J Neurochem. 2021 Jun;157(6):2128-2144. doi: 10.1111/jnc.15323. Epub 2021 Mar 5.PMID: 33583024

Early Long-Term Memory Impairment and Changes in the Expression of Synaptic Plasticity-Associated Genes, in the McGill-R-Thy1-APP Rat Model of Alzheimer's-Like Brain Amyloidosis.

Habif M, Do Carmo S, Báez MV, Colettis NC, Cercato MC, Salas DA, Acutain MF, Sister CL, Berkowicz VL, Canal MP, González Garello T, Cuello AC, Jerusalinsky DA.Front Aging Neurosci. 2021 Jan 22;12:585873. doi: 10.3389/fnagi.2020.585873. eCollection 2020.PMID: 33551786

Nerve growth factor (NGF) pathway biomarkers in Down syndrome prior to and after the onset of clinical Alzheimer's disease: A paired CSF and plasma study.

Pentz R, Iulita MF, Ducatenzeiler A, Videla L, Benejam B, Carmona‐Iragui M, Blesa R, Lleó A, Fortea J, Cuello AC.Alzheimers Dement. 2021 Apr;17(4):605-617. doi: 10.1002/alz.12229. Epub 2020 Nov 23.PMID: 33226181

Connecting the "Dots": From Free Radical Lipid Autoxidation to Cell Pathology and Disease.

Foret MK, Lincoln R, Do Carmo S, Cuello AC, Cosa G.Chem Rev. 2020 Dec 9;120(23):12757-12787. doi: 10.1021/acs.chemrev.0c00761. Epub 2020 Nov 19.PMID: 33211489

Evolution of neuroinflammation across the lifespan of individuals with Down syndrome.

Flores-Aguilar L, Iulita MF, Kovecses O, Torres MD, Levi SM, Zhang Y, Askenazi M, Wisniewski T, Busciglio J, Cuello AC.Brain. 2020 Dec 1;143(12):3653-3671. doi: 10.1093/brain/awaa326.PMID: 33206953

A new role for matrix metalloproteinase-3 in the NGF metabolic pathway: Proteolysis of mature NGF and sex-specific differences in the continuum of Alzheimer's pathology.

Pentz R, Iulita MF, Mikutra-Cencora M, Ducatenzeiler A, Bennett DA, Cuello AC.Neurobiol Dis. 2021 Jan;148:105150. doi: 10.1016/j.nbd.2020.105150. Epub 2020 Oct 30.PMID: 33130223

eIF2α controls memory consolidation via excitatory and somatostatin neurons.

Sharma V, Sood R, Khlaifia A, Eslamizade MJ, Hung TY, Lou D, Asgarihafshejani A, Lalzar M, Kiniry SJ, Stokes MP, Cohen N, Nelson AJ, Abell K, Possemato AP, Gal-Ben-Ari S, Truong VT, Wang P, Yiannakas A, Saffarzadeh F, Cuello AC, Nader K, Kaufman RJ, Costa-Mattioli M, Baranov PV, Quintana A, Sanz E, Khoutorsky A, Lacaille JC, Rosenblum K, Sonenberg N.Nature. 2020 Oct;586(7829):412-416. doi: 10.1038/s41586-020-2805-8. Epub 2020 Oct 7.PMID: 33029011

Amyloid-beta modulates the association between neurofilament light chain and brain atrophy in Alzheimer's disease.

Kang MS, Aliaga AA, Shin M, Mathotaarachchi S, Benedet AL, Pascoal TA, Therriault J, Chamoun M, Savard M, Devenyi GA, Mathieu A, Chakravarty MM, Sandelius Å, Blennow K, Zetterberg H, Soucy JP, Cuello AC, Massarweh G, Gauthier S, Rosa-Neto P; Alzheimer’s Disease Neuroimaging Initiative.Mol Psychiatry. 2020 Jun 26. doi: 10.1038/s41380-020-0818-1. Online ahead of print.PMID: 32591633

The human brain NGF metabolic pathway is impaired in the pre-clinical and clinical continuum of Alzheimers disease.

Pentz R, Iulita MF, Ducatenzeiler A, Bennett DA, Cuello AC.Mol Psychiatry. 2020 Jun 2. doi: 10.1038/s41380-020-0797-2. Online ahead of print.PMID: 32488129

Early intraneuronal amyloid triggers neuron-derived inflammatory signaling in APP transgenic rats and human brain.

Welikovitch LA, Do Carmo S, Maglóczky Z, Malcolm JC, Lőke J, Klein WL, Freund T, Cuello AC.Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6844-6854. doi: 10.1073/pnas.1914593117. Epub 2020 Mar 6.PMID: 3214414

Future avenues for Alzheimer's disease detection and therapy: liquid biopsy, intracellular signaling modulation, systems pharmacology drug discovery.

Hampel H, Vergallo A, Caraci F, Cuello AC, Lemercier P, Vellas B, Giudici KV, Baldacci F, Hänisch B, Haberkamp M, Broich K, Nisticò R, Emanuele E, Llavero F, Zugaza JL, Lucía A, Giacobini E, Lista S; Alzheimer Precision Medicine Initiative.Neuropharmacology. 2021 Mar 1;185:108081. doi: 10.1016/j.neuropharm.2020.108081. Epub 2020 May 11.PMID: 32407924

NP03, a Microdose Lithium Formulation, Blunts Early Amyloid Post-Plaque Neuropathology in McGill-R-Thy1-APP Alzheimer-Like Transgenic Rats.

Wilson EN, Do Carmo S, Welikovitch LA, Hall H, Aguilar LF, Foret MK, Iulita MF, Jia DT, Marks AR, Allard S, Emmerson JT, Ducatenzeiler A, Cuello AC.J Alzheimers Dis. 2020;73(2):723-739. doi: 10.3233/JAD-190862.PMID: 31868669

A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease.

Hampel H, Caraci F, Cuello AC, Caruso G, Nisticò R, Corbo M, Baldacci F, Toschi N, Garaci F, Chiesa PA, Verdooner SR, Akman-Anderson L, Hernández F, Ávila J, Emanuele E, Valenzuela PL, Lucía A, Watling M, Imbimbo BP, Vergallo A, Lista S.Front Immunol. 2020 Mar 31;11:456. doi: 10.3389/fimmu.2020.00456. eCollection 2020.PMID: 32296418

Ted Sourkes, Moussa Youdim and I.

Cuello AC.J Neural Transm (Vienna). 2020 Feb;127(2):119-123. doi: 10.1007/s00702-019-02135-4. Epub 2020 Jan 18.PMID: 31953605

Perturbed mitochondria-ER contacts in live neurons that model the amyloid pathology of Alzheimer's disease.

Martino Adami PV, Nichtová Z, Weaver DB, Bartok A, Wisniewski T, Jones DR, Do Carmo S, Castaño EM, Cuello AC, Hajnóczky G, Morelli L.J Cell Sci. 2019 Oct 22;132(20):jcs229906. doi: 10.1242/jcs.229906.PMID: 3151527

Blood-based systems biology biomarkers for next-generation clinical trials in Alzheimer's disease .

Hampel H, Vergallo A, Afshar M, Akman-Anderson L, Arenas J, Benda N, Batrla R, Broich K, Caraci F, Cuello AC, Emanuele E, Haberkamp M, Kiddle SJ, Lucía A, Mapstone M, Verdooner SR, Woodcock J, Lista S.Dialogues Clin Neurosci. 2019;21(2):177-191. doi: 10.31887/DCNS.2019.21.2/hhampel.PMID: 31636492

Aβ-induced vulnerability propagates via the brain's default mode network.

Pascoal TA, Mathotaarachchi S, Kang MS, Mohaddes S, Shin M, Park AY, Parent MJ, Benedet AL, Chamoun M, Therriault J, Hwang H, Cuello AC, Misic B, Soucy JP, Aston JAD, Gauthier S, Rosa-Neto P.Nat Commun. 2019 Jun 4;10(1):2353. doi: 10.1038/s41467-019-10217-w.PMID: 31164641

Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease.

Chiesa PA, Cavedo E, Vergallo A, Lista S, Potier MC, Habert MO, Dubois B, Thiebaut de Schotten M, Hampel H; INSIGHT-preAD study group; Alzheimer Precision Medicine Initiative (APMI).Alzheimers Dement. 2019 Jul;15(7):940-950. doi: 10.1016/j.jalz.2019.03.006. Epub 2019 May 18.PMID: 31113760

Plasma amyloid β 40/42 ratio predicts cerebral amyloidosis in cognitively normal individuals at risk for Alzheimer's disease.

Vergallo A, Mégret L, Lista S, Cavedo E, Zetterberg H, Blennow K, Vanmechelen E, De Vos A, Habert MO, Potier MC, Dubois B, Neri C, Hampel H; INSIGHT-preAD study group; Alzheimer Precision Medicine Initiative (APMI).Alzheimers Dement. 2019 Jun;15(6):764-775. doi: 10.1016/j.jalz.2019.03.009. Epub 2019 May 18.PMID: 31113759

Neuropathological changes and cognitive deficits in rats transgenic for human mutant tau recapitulate human tauopathy.

Malcolm JC, Breuillaud L, Do Carmo S, Hall H, Welikovitch LA, Macdonald JA, Goedert M, Cuello AC.Neurobiol Dis. 2019 Jul;127:323-338. doi: 10.1016/j.nbd.2019.03.018. Epub 2019 Mar 21.PMID: 30905766

Experimental Pharmacology in Transgenic Rodent Models of Alzheimer's Disease.

Cuello AC, Hall H, Do Carmo S.Front Pharmacol. 2019 Mar 4;10:189. doi: 10.3389/fphar.2019.00189. eCollection 2019.PMID: 30886583

The Brain NGF Metabolic Pathway in Health and in Alzheimer's Pathology.

Cuello AC, Pentz R, Hall H.Front Neurosci. 2019 Feb 12;13:62. doi: 10.3389/fnins.2019.00062. eCollection 2019.PMID: 30809111

Identification and Preliminary Validation of a Plasma Profile Associated with Cognitive Decline in Dementia and At-Risk Individuals: A Retrospective Cohort Analysis.

Iulita MF, Ganesh A, Pentz R, Flores Aguilar L, Gubert P, Ducatenzeiler A, Christie S, Wilcock GK, Cuello AC.J Alzheimers Dis. 2019;67(1):327-341. doi: 10.3233/JAD-180970.PMID: 30636741.

Revisiting the Cholinergic Hypothesis in Alzheimer's Disease: Emerging Evidence from Translational and Clinical Research.

Hampel H, Mesulam MM, Cuello AC, Khachaturian AS, Vergallo A, Farlow MR, Snyder PJ, Giacobini E, Khachaturian ZS.J Prev Alzheimers Dis. 2019;6(1):2-15. doi: 10.14283/jpad.2018.43.PMID: 30569080

Effect of antioxidant supplements on lipid peroxidation levels in primary cortical neuron cultures.

Foret MK, Do Carmo S, Lincoln R, Greene LE, Zhang W, Cuello AC, Cosa G.Free Radic Biol Med. 2019 Jan;130:471-477. doi: 10.1016/j.freeradbiomed.2018.11.019. Epub 2018 Nov 19.PMID: 30465825

Evidence of intraneuronal Aβ accumulation preceding tau pathology in the entorhinal cortex.

Welikovitch LA, Do Carmo S, Maglóczky Z, Szocsics P, Lőke J, Freund T, Cuello AC.Acta Neuropathol. 2018 Dec;136(6):901-917. doi: 10.1007/s00401-018-1922-z. Epub 2018 Oct 25.PMID: 30362029

Platelets Bioenergetics Screening Reflects the Impact of Brain Aβ Plaque Accumulation in a Rat Model of Alzheimer.

Prestia FA, Galeano P, Martino Adami PV, Do Carmo S, Castaño EM, Cuello AC, Morelli L.Neurochem Res. 2019 Jun;44(6):1375-1386. doi: 10.1007/s11064-018-2657-x. Epub 2018 Oct 24.PMID: 30357651

Microdose Lithium NP03 Diminishes Pre-Plaque Oxidative Damage and Neuroinflammation in a Rat Model of Alzheimer's-like Amyloidosis.

Wilson EN, Do Carmo S, Iulita MF, Hall H, Austin GL, Jia DT, Malcolm JC, Foret MK, Marks AR, Butterfield DA, Cuello AC.Curr Alzheimer Res. 2018;15(13):1220-1230. doi: 10.2174/1567205015666180904154446.PMID: 30182855